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| Silva-Leite, Kaira Emanuella Sales da; Queiroz, Cinthia Silva; Madeira, Juliana da Costa; Soares, Pedro Marcos Gomes; Pereira, Maria Gonçalves; Assreuy, Ana Maria Sampaio. |
| Mimosa tenuiflora (Mimosaceae) or “jurema-preta” is well distributed in the northeast Brazil, being popularly used to treat skin lesions, burns and inflammation. The healing effect of the alcoholic extract prepared with its barks corroborates the popular use. This study aimed to evaluate the inflammatory response of polysaccharides extracted from M. tenuiflora barks (EP-Mt) by methanol/NaOH and ethanol precipitation. Inflammatory activity was assessed in rat models of acute inflammation (paw edema and peritonitis), by the following parameters: edema, vascular permeability, leukocyte migration, myeloperoxidase activity and pharmacological modulation of nitric oxide and prostaglandins. EP-Mt presented 3.8% yield, 41% carbohydrate and 0.34% protein. EP-Mt... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 2.00.00.00-6 e 2.10.00.00-0 Mimosaceae; Medicinal plant; Carbohydrate; Inflammation 2.10.06.00-8. |
| Ano: 2016 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/32234 |
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| Aragão, Gislei Frota; Nonato, Dayanne Terra Tenório; Ponte, Edson Lopes da; Sales, Jonathan Rodrigues; Alencar, Daniel Barroso; Sampaio, Silvana Saker; Camelo Chaves, Edna Maria; Assreuy, Ana Maria Sampaio. |
| This study aimed to investigate the EEAm effect in mice models of nociception, inflammation and in behavioral tests evaluating the central nervous system. EEAm had inhibitory effects in the following tests: acetic acid-induced writhing (78%); formalin (62% - inflammatory phase); open field (46%). EEAm increased the nociceptive latency (56%) in tail flick test and increased the death-latency by 36% in the pentylenetetrazole-induced seizure model. Moreover, EEAm inhibited paw edema (82%) and peritonitis (45%) induced by carrageenan. In conclusion, EEAm presents antinociceptive, anti-inflammatory and anticonvulsant effects involving peripheral and central-acting mechanisms in mice. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute inflammatory process; Antinociception; Epilepsy; Red seaweed. |
| Ano: 2016 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/32361 |
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| Assreuy, Ana Maria Sampaio; Adjafre, Beatriz Lima; Sousa, Évilla Rayanne Oliveira; Alves, Ana Paula Negreiros Nunes; Pires, Alana de Freitas; Quinet, Yves; Mota, Mário Rogério Lima. |
| Arthropod venoms are potential sources of bioactive substances, providing tools for the validation of popular use and new drugs design. Ants belonging to the genus Dinoponera are used in the folk medicine to treat inflammatory conditions. It was previously demonstrated that the venom of the giant ant Dinoponera quadriceps (DqV), containing a mixture of polypeptides, elicit antinociceptive effect in mice models of chemical, mechanical and thermal nociception. The aim of this study was to evaluate DqV antiinflammatory and antihypernociceptive effects in a mice model of traumatic cutaneous wound. Colonies of D. quadriceps were collected in the ‘‘Serra de Maranguape’’ (State of Ceará, northeastern Brazil), a small mountain range located on the coastal zone,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: DqV; Hypernociception; Leukocyte infiltrate; Scar. |
| Ano: 2020 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/47680 |
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